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These metabotype-dependent differences provide a mechanistic basis for interindividual variability in the anti-inflammatory efficacy of EC and should be carefully considered when interpreting experimental and clinical findings on EC

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In osteosarcoma (HOS and 143B), UA acts synergistically with cisplatin to activate autophagic degradation of ferritin, leading to intracellular accumulation of iron ions, generating lipid peroxidation and triggering iron death [1049]

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Side effects are mild when medically supervised

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